abstract：OBJECT:The use of T2 relaxometry was investigated to detect non-sclerotic epileptogenic abnormality of the hippocampus in presurgical evaluation of temporal lobe epilepsy (TLE). METHODS:This prospective study included 30 patients who underwent hippocampectomy as part of surgical treatment of refractory TLE. Ten patien...

journal_title：Epilepsy research

authors： Sato S,Iwasaki M,Suzuki H,Mugikura S,Jin K,Tominaga T,Takase K,Takahashi S,Nakasato N

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Understanding the overall and common metabolic changes of seizures can provide novel clues for their control and prevention. Here, we aim to investigate the global metabolic feature of serum for three types of seizures. METHODS:We recruited 27 patients who had experienced a seizure within 48h (including 11 w...

journal_title：Epilepsy research

authors： Wang D,Wang X,Kong J,Wu J,Lai M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Little is known, so far, about the cerebral structural abnormalities in drug-naïve patients with childhood absence epilepsy (CAE). We aimed to investigate regional grey matter (GM) volume differences using voxel-based morphometry (VBM) in patients and closely matched healthy control subjects. METHODS:Twenty...

journal_title：Epilepsy research

authors： Wang G,Dai ZY,Song W,Wang S,Shi H,Pan P,Chen F,Xu Y,Zhong J

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To study the different epilepsy syndromes that included epileptic spasms (ES) in clusters without hypsarrhythmia (WoH). METHODS:Between 2/1990 and 7/2013, we registered 48 patients with the electroclinical diagnostic criteria of ES in clusters WoH. RESULTS:We recognized two subgroups. In the first subgroup ...

journal_title：Epilepsy research

authors： Caraballo RH,Fortini S,Reyes G,Carpio Ruiz A,Sanchez Fuentes SV,Ramos B

更新日期：2016-07-01 00:00:00

abstract：:Generic substitution of antiepileptic drugs (AEDs) is still a matter of controversy and concern among clinicians and patients. We aimed to assess intrasubject variation in plasma concentrations of lamotrigine (LTG), levetiracetam (LEV) and topiramate (TPM) after generic substitution compared with a stable brand-name d...

journal_title：Epilepsy research

authors： Contin M,Alberghini L,Candela C,Benini G,Riva R

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:We sought to systematically review and perform a meta-analysis of the magnetic resonance spectroscopy (MRS) findings regarding juvenile myoclonic epilepsy (JME). METHODS:We searched for studies in the PubMed, Web of Science, and Embase electronic databases. Two authors collected articles and extracted data ind...

journal_title：Epilepsy research

authors： Zhang L,Li H,Hong P,Zou X

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Using the gamma-butyrolactone (GBL) model of absence seizures in Long-Evans rats, this study investigated if 2.5-6 Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of the hippocampus affected PDs. METHODS:Local fiel...

journal_title：Epilepsy research

authors： Arcaro J,Ma J,Chu L,Kuo M,Mirsattari SM,Stan Leung L

更新日期：2016-02-01 00:00:00

abstract：:This was an open-label study (N01281 [NCT00419393]) assessing the long-term safety of extended-release levetiracetam (LEV XR) in patients with partial-onset seizures (POS); the study was a follow-up to a double-blind, randomized, historical controlled, multicenter, conversion to monotherapy study (N01280 [NCT00419094]...

journal_title：Epilepsy research

authors： Chung S,Ceja H,Gawłowicz J,McShea C,Schiemann J,Lu S

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To validate the Chinese version of the Generalized Anxiety Disorder-7 (GAD-7) in Chinese people with epilepsy (PWE). METHODS:A consecutive cohort of PWE from the West China Hospital was recruited. Each patient received a psychiatric evaluation comprising the Mini International Neuropsychiatric Interview (MIN...

journal_title：Epilepsy research

authors： Tong X,An D,McGonigal A,Park SP,Zhou D

更新日期：2016-02-01 00:00:00

abstract：:Mutations in voltage-gated sodium channel genes cause several types of human epilepsies. Often, individuals with the same sodium channel mutation exhibit diverse phenotypes. This suggests that factors beyond the primary mutation influence disease severity, including genetic modifiers. Mouse epilepsy models with voltag...

journal_title：Epilepsy research

authors： Hawkins NA,Kearney JA

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur i...

journal_title：Epilepsy research

authors： Rozendaal YJ,van Luijtelaar G,Ossenblok PP

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:The anticonvulsant effects of melatonin (MT) have been demonstrated in several different experimental seizure models. Thus, the present study aimed to determine the anticonvulsant efficacy of MT, the optimum time for its administration prior to the induction of a seizure, and its effective dose in a rat mo...

journal_title：Epilepsy research

authors： Aydin L,Gundogan NU,Yazici C

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder caused by mutations of the ALDH7A1 gene. We aimed to analyze the relations between the clinical diagnosis and treatment of PDE and ALDH7A1 gene mutations in Chinese PDE patients. METHODS:The clinical manifestations, diagnosis and treatm...

journal_title：Epilepsy research

authors： Xue J,Qian P,Li H,Wu Y,Liu X,Yang Z

更新日期：2015-12-01 00:00:00

abstract：:Seletracetam (SEL), an analog of the antiepileptic drug levetiracetam (LEV), decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A with a higher affinity than LEV. Experiments were performed to determine if SEL, like LEV, reduces the later EPSPs in long trains of stim...

journal_title：Epilepsy research

authors： Yang X,Meehan AL,Rothman SM,Dubinsky JM

更新日期：2015-11-01 00:00:00

abstract：:To help identify patients at greatest risk for sudden unexpected death in epilepsy (SUDEP), screening inventories like the SUDEP-7 Inventory can be useful. In this study, we examined the strength of association between this inventory's risk factors and postictal generalized EEG suppression (PGES), a biomarker of SUDEP...

journal_title：Epilepsy research

authors： Moseley BD,DeGiorgio CM

更新日期：2015-11-01 00:00:00

abstract：:Posttraumatic epilepsy (PTE) has been modeled with different techniques of experimental traumatic brain injury (TBI) using mice and rats at various ages. We hypothesized that the technique of controlled cortical impact (CCI) could be used to establish a model of PTE in young adult rats. A total of 156 male Sprague-Daw...

journal_title：Epilepsy research

authors： Kelly KM,Miller ER,Lepsveridze E,Kharlamov EA,Mchedlishvili Z

更新日期：2015-11-01 00:00:00

abstract：:Huperzine A (HupA) is a naturally occurring compound found in the firmoss Huperzia serrata. While HupA is a potent acetylcholinesterase inhibitor, its full pharmacologic profile is incompletely described. Since previous works suggested a capacity for HupA to prophylax against seizures, we tested the HupA antiepileptic...

journal_title：Epilepsy research

authors： Gersner R,Ekstein D,Dhamne SC,Schachter SC,Rotenberg A

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drug-naïve Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and healthy controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. METHODS:Resting state fMR...

journal_title：Epilepsy research

authors： Zeng H,Ramos CG,Nair VA,Hu Y,Liao J,La C,Chen L,Gan Y,Wen F,Hermann B,Prabhakaran V

更新日期：2015-10-01 00:00:00

abstract：:Granule cell dispersion (GCD), a structural abnormality, is characteristic of temporal lobe epilepsy (TLE). Eugenol (EUG) is an essential component of medicinal herbs and is suggested to exert anticonvulsant activity. However, it is unclear whether EUG ameliorates the abnormal morphological changes in granule cells in...

journal_title：Epilepsy research

authors： Jeong KH,Lee DS,Kim SR

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:High frequency oscillations (HFOs) have provided a new insight in understanding ictogenesis and seizure localization. In absence seizures, HFOs were predominantly localized in the medial prefrontal cortex (MPFC) in MEG studies. METHODS:We studied HFOs (80-250 Hz) in scalp EEGs in patients with absence epile...

journal_title：Epilepsy research

authors： Chaitanya G,Sinha S,Narayanan M,Satishchandra P

更新日期：2015-09-01 00:00:00

abstract：:The prevailing understanding of generalized epilepsy is shaped by the traditional definition that "the responsible neuronal discharge takes place, if not throughout the entire grey matter, then at least in the greater part of it and simultaneously on both sides". This view is no longer tenable since concurrent finding...

journal_title：Epilepsy research

authors： Wolf P,Yacubian EM,Avanzini G,Sander T,Schmitz B,Wandschneider B,Koepp M

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Epilepsy is associated with an increased mortality. This study estimates the effects of co-morbid disorders on short-term and long-term mortality and presents cause-specific mortality for children and young adults with epilepsy. METHODS:We established a population-based cohort of 1,855,946 children born in Den...

journal_title：Epilepsy research

authors： Christensen J,Pedersen CB,Sidenius P,Olsen J,Vestergaard M

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:In Rasmussen syndrome (RS), in addition to the predominant involvement of cytotoxic T cells, heterogeneous autoantibodies against neural molecules are also found, but their function has not been elucidated. We examined antibodies to N-methyl-d-aspartate (NMDA) type glutamate receptor (GluR) subunits (GluN2B &...

journal_title：Epilepsy research

authors： Fukuyama T,Takahashi Y,Kubota Y,Mogami Y,Imai K,Kondo Y,Sakuma H,Tominaga K,Oguni H,Nishimura S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in order to inv...

journal_title：Epilepsy research

authors： Menezes Cordeiro I,von Ellenrieder N,Zazubovits N,Dubeau F,Gotman J,Frauscher B

更新日期：2015-07-01 00:00:00

abstract：:Recognition of the role of genetics in the epilepsies has increased dramatically, impacting on clinical practice across many epilepsy syndromes. There is limited research investigating the impact of gene identification on individuals and families with epilepsy. While research has focused on the impact of delivering ge...

journal_title：Epilepsy research

authors： Vears DF,Dunn KL,Wake SA,Scheffer IE

更新日期：2015-05-01 00:00:00

abstract：:Food intake triggers convulsions in fasted BALB/c mice and Wistar albino rats treated with antimuscarinic drugs, scopolamine or atropine. Inbred strain studies have yielded considerable information regarding genetic influences on seizure susceptibility and factors contribute to epileptogenesis in rodents. This study, ...

journal_title：Epilepsy research

authors： Enginar N,Nurten A,Türkmen AZ,Çağla B

更新日期：2015-05-01 00:00:00

abstract：:Surgical treatment of mesial temporal lobe epilepsy (mTLE) patients involves the removal either of the left or the right hippocampus. Since the mesial temporal lobe is responsible for emotion recognition abilities, we aimed to assess facial emotion recognition (FER) in two homogeneous patient cohorts that differed onl...

journal_title：Epilepsy research

authors： Wendling AS,Steinhoff BJ,Bodin F,Staack AM,Zentner J,Scholly J,Valenti MP,Schulze-Bonhage A,Hirsch E

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:We investigated long term prognosis of Lennox-Gastaut syndrome (LGS) with active application of recent advanced treatment modalities such as ketogenic diet (KD) or epilepsy surgery (ES). METHODS:We retrospectively evaluated 68 patients with LGS, aged 18-35 years. We assessed seizure outcomes for a range of the...

journal_title：Epilepsy research

authors： Kim HJ,Kim HD,Lee JS,Heo K,Kim DS,Kang HC

更新日期：2015-02-01 00:00:00

abstract：:Children with epilepsy face significant cognitive and behavioral impairments. These impairments are due to a poorly characterized interaction between the underlying etiology, the effect of seizures and the effect of medication. The large variation in these factors make understanding the main drivers of cognitive impai...

journal_title：Epilepsy research

authors： Jellett AP,Jenks K,Lucas M,Scott RC

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Due to pharmacoresistant seizures and the underutilization of surgical treatments, a large number of temporal lobe epilepsy (TLE) patients experience seizures for years or decades. The goal of this study was to generate a predictive model of duration of disease with the least number of parameters possible in...

journal_title：Epilepsy research

authors： Morgan VL,Conrad BN,Abou-Khalil B,Rogers BP,Kang H

更新日期：2015-02-01 00:00:00

abstract：:The deletion of a sodium channel gene cluster located on chromosome 2q24.3 is associated with variable epilepsy phenotypes, including Dravet syndrome and migrating partial seizures of infancy. Although SCN1A is considered as the major contributor to the epilepsy phenotype, the role of other sodium channel genes that m...

journal_title：Epilepsy research

authors： Lim BC,Hwang H,Kim H,Chae JH,Choi J,Kim KJ,Hwang YS,Yum MS,Ko TS

更新日期：2015-01-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) has been modeled in mice using pilocarpine induction, with variable results depending on specific strains. To allow efficient xenotransplantation for the purpose of optimizing potential cell-based therapy of human TLE, we have determined the optimal dosing strategy to produce spontaneous r...

journal_title：Epilepsy research

authors： Leung A,Ahn S,Savvidis G,Kim Y,Iskandar D,Luna MJ,Kim KS,Cunningham M,Chung S

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia (FCD) has been recognized as one of the most frequent causes of drug resistant epilepsy, especially in children. In infancy, onset of FCD-related epilepsy is substantially characterized by epileptic spasms (ES) or focal seizures. Which elements pertaining to the FCD are responsible for ...

journal_title：Epilepsy research

authors： Serino D,Freri E,Ragona F,D'Incerti L,Bernardi B,Di Ciommo V,Granata T,Vigevano F,Fusco L

更新日期：2015-01-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common type of epilepsy with about one third of TLE patients being refractory to antiepileptic drugs. Knowledge about the mechanisms underlying seizure activity is fundamental to the discovery of new drug targets. Brain Na(+),K(+)-ATPase activity contributes to the maintenance ...

journal_title：Epilepsy research

authors： Funck VR,Ribeiro LR,Pereira LM,de Oliveira CV,Grigoletto J,Fighera MR,Royes LF,Furian AF,Oliveira MS

更新日期：2014-12-01 00:00:00

abstract：:The 5-hydroxytryptamine-1A (5-HT1A) receptors are known to be involved in the inhibition of seizures in epilepsy. Moreover, studies propose a role for the 5-HT1A receptor in memory function; it is believed that the higher density of this receptor in the hippocampus plays an important role in its regulation. Positron e...

journal_title：Epilepsy research

authors： Cuellar-Herrera M,Velasco AL,Velasco F,Trejo D,Alonso-Vanegas M,Nuche-Bricaire A,Vázquez-Barrón D,Guevara-Guzmán R,Rocha L

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:To perform a systematic review and meta-analysis to identify risk factors associated with early seizure (ES) or late seizure (LS) onset in adults following stroke. DATA SOURCES:Electronic databases (MEDLINE and EMBASE), archives of stroke or epilepsy patients, and bibliographies of relevant articles, which wer...

journal_title：Epilepsy research

authors： Zhang C,Wang X,Wang Y,Zhang JG,Hu W,Ge M,Zhang K,Shao X

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy syndrome. Under appropriate antiepileptic drugs (AED) up to 85% of patients become seizure-free, but many may have a relapse after AED withdrawal. METHODS:We retrospectively studied 242 patients with JME at the Department of Neurology, Me...

journal_title：Epilepsy research

authors： Höfler J,Unterberger I,Dobesberger J,Kuchukhidze G,Walser G,Trinka E

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Grammar is a core component of the language system, yet it is rarely assessed during the Wada (intracarotid amobarbital) test. It is hypothesized that adding grammar tests to the recovery phase of the Wada test will increase our ability to lateralize language function. METHOD:Sixteen individuals (nine fem...

journal_title：Epilepsy research

authors： Połczyńska M,Curtiss S,Walshaw P,Siddarth P,Benjamin C,Moseley BD,Vigil C,Jones M,Eliashiv D,Bookheimer S

更新日期：2014-12-01 00:00:00

abstract：AIM:Seizures originating from the parietal lobe can demonstrate variable semiology. Our aim was to describe the electroclinical features of seizures originating from the mesial parietal lobe. METHOD:We identified four patients through the Comprehensive Epilepsy Program at our institution, who had strong evidence of a ...

journal_title：Epilepsy research

authors： Khan SA,Carney PW,Archer JS

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the agreement between magnetoencephalography (MEG) and intracranial electroencephalography (ICEEG) results, to determine the characteristics that lead to concordance, and to assess how these factors relate to favorable epilepsy surgery outcome. MATERIALS:This retrospective study reviewed 50 pati...

journal_title：Epilepsy research

authors： Almubarak S,Alexopoulos A,Von-Podewils F,Wang ZI,Kakisaka Y,Mosher JC,Bulacio J,González-Martínez J,Bingaman W,Burgess RC

更新日期：2014-11-01 00:00:00